Brother of the better-known Virginio Cesarini (1596–1624) to whom Galileo Galilei (1564–1642) addressed Il Saggiatore [The Assayer] (Rome, 1623) in the form of a letter.

Ferdinando Cesarini, as a referendarius utriusque signaturae and patron, corresponded with Benedetto Castelli (1577/8-1643), who described the Galilean thermoscope to him in a letter of September 20, 1638.

[2] Father Castelli also invited him to spread the Discorso sulla calamita [Discourse on the loadstone], also dedicated to Cesarini, within a limited circle of "trust" people.

[4] Cesarini also had contacts with Giovanni Ciampoli, who presented him in a poem[5] and with whom, in the late nineteenth century, he was counted among the prelates of his era inclined "to promote the progress of science".

[9][10] Cesarini died at age forty-two, leaving as his executor and heir Cardinal Federico Sforza.