[2] He went to India, with his elder brother - the aforementioned Duarte de Lemos, later 3rd Lord of Trofa - in the armada that left Lisbon in 1508.

The diplomatic contacts maintained by Fernão Gomes de Lemos with the Safavid Shah were publicly cordial, but in private the Persian sovereign expressed his annoyance with the Portuguese occupation of Hormuz.

[7][8] The governor in Goa, Dom Duarte de Meneses, agreed with Lemos' opinion, and reinforced it by stating that in Ceylon only the cinnamon trade was important, everything else being "of little interest".

In Colombo, only the head of the factory and alcaide, Nuno Freire de Andrade, would remain, with 20 soldiers; The viceroy Vasco da Gama, in Goa, wrote in the meantime to the King of Kotte, Bhuvanekabãhu VII, informing him of the decision to destroy the fortress and to keep only a feitoria in Colombo, explaining that "the fortress was a cause of trouble; to satisfy Your Highness I thus order it destroyed and I only leave there a Factor to collect the tributes and trade in spices useful to the kingdom [of Portugal]".

[4] He is one of the four brothers of the above-mentioned António de Lemos - the youngest son of the 2nd Lords of Trofa - whom the governor of Portuguese India, Martim Afonso de Sousa, writing to King John III from Goa, on December 1, 1543, mentions as having " died in the service of the King".