Manuel Fernando Serrano Uribe (May 30, 1789 – February 15, 1819) was a Neogranadine statesman, lawyer, and officer who became Governor of the Province of Pamplona and wrote its Constitution in 1815.

He was sent to finish his studies in Santafé de Bogotá in the Our Lady of the Rosary University where he graduated with a Doctorate in Law.

Upon his return to Pamplona he met Rosa Calderón Estrada, daughter of a noble and rich family of Girón, with whom he falls in love and gets married.

Serrano was forced to flee Pamplona, selling all his positions and leaving his family behind, and join the army to protect the country.

Serrano’s wife, Rosa Calderón Estrada, and their four children, Silvestre, Francisca, Juan Estanislao and Rudecinda, the oldest of only eight years of age, had to flee Pamplona.

After the capture of the president Custodio García Rovira on July 10, 1816, the country had no leader; this caused repeated defeats and confused the troops, giving a clear advantage to the enemy.