The America models were equipped with large V12 engines and often had custom bodywork done by famous coachbuilders in Italy.

Built as a successor to the 342 America, The 375 used the new 4,522.08 cc (4.5 L) "long block" Lampredi designed V12 engine that was rated at 300 PS (221 kW; 296 hp) at 6,300 rpm, with three Weber 40DCF (or DCZ) carburettors.

The engine had an increased displacement up to 4,962.96 cc (5.0 L) and was rated at 340 PS (250 kW; 335 hp) at 6,000 rpm thanks to three Weber 40DCF carburettors.

The 410 Superamerica had a new chassis, featuring independent coil spring front suspension and was the first Ferrari road car to use a five speed gearbox.

[8] In 1957, the carburetors were upgraded for Weber 46DCF3 units which resulted in an increased power output of 360 PS (265 kW; 355 hp).

The price was extremely high—at US$16,800, the 410 Superamerica offered at the New York Auto Show by importer Luigi Chinetti was more than twice as expensive as the Mercedes-Benz 300SL "Gullwing" exhibited by Max Hoffman.

[13] The 400 Superamerica debuted in 1959 as the production of the 410 ended, and was available as a coupe, spider, or cabriolet with custom Pinin Farina bodywork.

It had the smaller 3,967.44 cc (4.0 L) Colombo engine, which had similar power output as its predecessor at 340 PS (250 kW; 335 hp) at 7,000 rpm.

Breathing through six twin-choke Weber 40DCZ/6 carburettors, the V12 produced up to 400 PS (294 kW; 395 hp) at 6,500 rpm and could push the car to 280 kilometres per hour (174 mph).

[18] 36 cars were made from 1964 to 1966, including 12 improved Series II models with a 5-speed transmission in place of the earlier 4-speed plus overdrive.

The Series II cars can be recognized by having a triple louvre exhaust vent behind the front wheels, rather than the earlier 11-slot grilles.

The production total excludes a one-off 330 GT 2+2 produced with a Superfast-style body for Prince Bernhard of The Netherlands.

[19] Famous owners of the car include Prince Karim Aga Khan who bought the first 500 Superfast and the Shah of Iran who owned two.

Debuting at the Geneva Motor Show in 1966, just 14 examples were produced (including 2 in right hand drive) before production ended in 1967.

The chassis were sent to Pininfarina's Grugliasco plant to be bodied and trimmed and were then returned to Ferrari for fitment of the mechanical components.