Born in Turin to actors Federico Amendola and Amelia Ricci and the nephew of director and screenwriter Mario Amendola, he was among Italy's most accomplished actors who worked for cinema and television and also did extensive voice dubbing work.

[1] In 1945, Amendola made his voice-over debut dubbing over Vito Annicchiarico's role in the film Rome, Open City.

By 1968, Amendola began devoting most of his time to voice-over acting and eventually became well known as an Italian voice dubbing pioneer.

[2] He was best known as the Italian voice of famous actors including Al Pacino, Sylvester Stallone, Dustin Hoffman, Robert De Niro and Tomas Milian in a majority of their movies.

[4] From his relationship with his ex-wife Rita Savagnone who is a voice-over actress, he had two sons, Federico, who was named after his father and Claudio, who is also an actor.