She founded the Fiske Seminary boarding school in Urmia in West Azerbaijan Province, Qajar Iran.

[2] In 1843, she resigned her post at Mount Holyoke Seminary and went to Qajar Iran as a missionary among the Christian Assyrians (who were once called "Nestorians" by Americans during the late 18th century, but is now an outdated term).

[2] The Assyrian Church of the East of Urmia and Bishop Mar Yohannan, wanted literacy and education for women and Fisk had a leadership role in this goal.

[4] Fisk had labored in Iran for fifteen years, much of the time as teacher in a female seminary, she also served as a nurse and extended social support for some of her students.

At the time of her death, she was engaged in writing Recollections of Mary Lyon (Boston, 1866).