It was published in comic book format but contained text articles with photographs and background caricatures.

The articles were written by Barry Marx, Thomas Hill, and Joey Cavalieri and caricatures were provided by Steven Petruccio.

The cover art, featuring Clark Kent holding the "DC Bullet", was drawn by Curt Swan, Murphy Anderson, and Arne Starr.

These included comments by Daniel P. Moynihan, Richard Corben, Ray Bradbury, Gloria Steinem, Mort Walker, Milton Glaser, Walter Koenig, Gene Siskel, Stephen King, Gene Simmons, Jim Henson, David L. Wolper, Stan Lee, Susan Stamberg, Roger Ebert, Brooke Shields, Carol Bellamy, and Whoopi Goldberg.

Fifty Who Made DC Great has been used as a cited reference source for several books.