Regular contributors to Fightin' Air Force included Dick Giordano (who illustrated many early covers), Sam Glanzman, Jack Keller, Rocke Mastroserio, Bill Molno, Charles Nicholas, Jack Abel, and inker Vince Alascia.

Most of the stories in Fightin' Air Force take place during World War II, telling tales of American pilots battling the Japanese and the Germans.

Regular text features told true stories of notable aircraft and famous aviation missions.

The title's last four issues (#50–53) hosted a recurring feature called "American Eagle", with art by Charles Nicholas and Vince Alascia.

The Eagles — a trio of flyers named "Reb" Folsom, "Hotrock" Hutchins, and "Ugly" Harrison Clymes — battled Baron von Kesselein, the "Flaming Sabre of Hitler", and other World War II villains.