He confirmed his allegiance to Andrea by accompanying him in his flight from Genoa after it was sacked by the Spanish in 1522 - the pair took four galleys and sailed to Monaco to enter the service of Francis I of France.
He probably took part with Andrea in his conspiracy against Luciano Grimaldi, the defence of Marseille from the sea in 1524, the supply chain down the Rhone, the lucky capture of Philibert of Chalon and the daring plan to spring Francis from captivity after the battle of Pavia.
Filippino took two ships to Portofino to assist in holding off an attack by doge Antoniotto Adorno in September 1526, which was aimed at relieving the blockade of Genoa.
When news of the Sack of Rome reached Andrea's fleet, it sailed from Liguria to Fiumicino to aid Clement - Filippino made a failed attempt to land a group of soldiers and spring the pope from his effective captivity in Castel Sant'Angelo.
He anchored in the Gulf of Salerno, blockading the city and killing Naples' governor Hugo of Moncada when he attempted a breakout by sea on 28 April.