In April 1528, the French commander Odet de Foix laid siege to the city while Andrea Doria's nephew Filippino organised a naval blockade.

The hill on which it stood is now known as Poggioreale, but was once called monte di Leutrecco or Lo Trecco,[2][3] using de Foix's Italian nickname.

Towards the end of April, [4] Naples' governor Hugo of Moncada was killed by two arquebusiers and thrown into the sea during an unsuccessful attempt to break through the naval blockade and reach the Gulf of Salerno.

[1] On 4 July, Doria lifted the naval blockade after Genoa switched allegiance to the Holy Roman Empire in exchange for the liberation and subjugation of Savoy.

The French gave up the siege at the end of August and tried to withdraw to Aversa, but were intercepted by an Imperial force, which captured Charles of Navarre and the famous military engineer Pietro Navarro.