He was the director of the scientific group affiliated with the first official mission sent to Persia in 1862, intended to re-establish diplomatic relations between the two countries.
[3] Later he became a senator of the Kingdom of Italy, but De Filippi set out in 1866 on a government-sponsored scientific voyage to circumnavigate the globe.
[4] The ship, the Italian corvette Magenta, sailed under the command of Vittorio Arminjon,[5][6] departing Montevideo on 2 February 1866.
However, De Filippi himself died en route at Hong Kong, on 9 February 1867 from serious dysentery and liver problems.
The scientific report was completed by his assistant, Professor Enrico Hillyer Giglioli, who returned to Italy in 1868.