[6] He is a record-breaking six-time world champion in the individual pursuit, winning a total of nine medals at the UCI Track Cycling World Championships, and part of the Olympic gold medal-winning team in the team pursuit at the 2020 Summer Olympics.

The son of former Italian Olympic sprint canoer Marco Ganna, Ganna emerged into the scene at the 2016 World Indoor Championships with an uncommon negative splits pursuit style of starting very slowly and falling behind, then winding up the speed in the second half to win.

[9] Between November 2019 and February 2020, Ganna set a world record for the individual pursuit on three occasions, lowering the mark from over 4 minutes, 5 seconds to a time of 4 minutes, 1.934 seconds at the 2020 UCI Track Cycling World Championships in Berlin.

[10][11] At the 2020 Summer Olympics held at Tokyo in 2021, together with Simone Consonni, Francesco Lamon and Jonathan Milan, he won the gold medal in the team pursuit.

The team set a new world record two times, both in the 3rd battery round against New Zealand and in the final against Denmark, at 3:42.02.