His first paintings of Saints Barbara and Thomas Aquinas for San Bartolomeo in Bologna (both in situ) date from 1779, were probably completed in collaboration with his father.
He is best known for his frescoes for various palaces in Bologna, including paintings of Allegory of Victory and the Muses for the Palazzo Comunale, Bologna and a Apotheosis of Hercules (entry staircase ceiling), an Apollo and the Hours in the grand salon, and a Dance of Nymphs and Cupids for a room in the Palazzo Hercolani.
In 1828 he painted five canvases for the ceiling of San Paolo in Monte at Bologna, now in the convent there.
Pedrini also painted various tombs in the Certosa, including those of Laghi, Carlo Chiesa e Vitale Bini, Ginevra Pepoli, Brigitta Giorgi Banti.
[2] In 1830 he completed the Delivery of the Keys for a church in San Pietro Capofiume near Bologna.