It had branches in North Carolina including in Asheville, Charlotte, Winston-Salem, and Wilmington and twelve branches in the South Carolina communities of Greenville, Greer, Anderson, Fountain Inn, Columbia, Orangeburg, Charleston, Cheraw, Dillon, Florence, Blacksburg and Rock Hill.

In the Thomasville area First Bank already had branches in High Point and Archdale.

[6] On October 1, 2008, First Bancorp announced the completion of its merger with Great Pee Dee Bancorp, Inc., the holding company of Sentry Bank and Trust, headquartered in Cheraw, South Carolina, with branches in Cheraw and Florence, $221 million in assets, and $155 million in deposits.

With deposits totalling $150 million, these were located in Abingdon, Blacksburg, Christiansburg, Fort Chiswell, Radford, Salem and Wytheville.

[12][13] A $175 million cash and stock deal with ASB Bancorp Inc. of Asheville, North Carolina, completed March 19, 2018, gave First Bancorp an additional $803 million in assets and 13 Asheville Savings Bank branches[14] in Buncombe, Madison, McDowell, Henderson and Transylvania Counties in Western North Carolina.