First Kiss (ファースト・キス, Faasuto Kisu) is a Japanese television drama series that aired on Fuji TV in 2007.

To treat her illness overseas, Mio has been living away from her older brother Kazuki for the past ten years.

After learning about the upcoming surgery, which she has only a fifty percent chance of survival, Mio decides to fly back to Japan to spend time with Kazuki.

However, their reunion is nothing but full of surprises as Mio has transformed from the innocent sickly girl Kazuki remembers from ten years ago into a sassy woman with an attitude.

Kazuki has difficulty dealing with his wickedly selfish younger sister, but soon learns about the truth of her medical condition and has a change of heart.