Initially, the church met in the Senate Chamber of the Republic of Texas, moving nearby to its first building in 1842.

First Presbyterian begun mission efforts to South Korea and Brazil.

[1] Vanderbloemen resigned in January 2007 after taking leave in December 2006.

[7] In February 2014 the church voted whether or not to sever ties with the PCUSA, following a policy change in which the latter organization opened the possibility of the ordination of openly gay ministers.

[8][9] In November 2016, the church decided to leave the PCUSA and align with ECO: A Covenant Order of Evangelical Presbyterians.