The organization's mission is to "understand the causes of Alzheimer's disease, improve the care of people living with it, and find a cure.

Since then, the lab has been led by interim Laboratory Head Marc Flajolet and advised by a Neuroscience Advisory Committee featuring multiple Nobel Laureates and faculty from The Rockefeller University.

[9] The longtime President and CEO of the Foundation was Kent Karosen, a New York City-based businessman and philanthropist.

Karosen was also the co-author, along with Chana Stiefel, of Why Can't Grandma Remember My Name?, a children's book about Alzheimer's disease published by the Foundation in 2016.

[17] Since 2007, the Foundation has published Preserving Your Memory, a triannual magazine available to subscribers which is also distributed to medical professionals nationally.