Designed by John Loughborough Pearson RA in the Gothic Revival style with a colourful mosaic interior, the chapel was built 1891 and 1892.

Set into an ogee arch is an aumbry adorned with an image of the Pelican in her Piety carved in white marble, erected in memory of Prince Francis of Teck, younger brother of Queen Mary, who died in 1910.

The organ gallery at the chapel's west end is surmounted by an arch decorated with a mosaic inscription of words from the Gloria in excelsis Deo:[2] GLORIA IN EXCELSIS DEO ET IN TERRA PAX HOMINIBUS BONÆ VOLUNTATIS(GLORY BE TO GOD IN THE HIGHEST AND ON EARTH PEACE TO MEN OF GOODWILL)The baptismal font is carved from a solid block of green marble and is adorned with the symbols of the Four Evangelists.

The inscription, "Nipson anomemata me monan opsin", is a palindrome in Ancient Greek as inscribed on a holy water font outside the Church of Hagia Sophia, Constantinople, in medieval times:[2] Νίψον ἀνομήματα, μὴ μόναν ὄψιν (Wash the sins, not only the face)Unusually, the chapel is aligned approximately on a north–south axis instead of the traditional alignment towards the liturgical east.

[8] The Richard Ingleby Gallery hosted an exhibition during Frieze London in October 2017, including works by David Batchelor, Jonathan Owen, Kevin Harman and Peter Liversidge.

[10] The TJ Boulting gallery hosted Stephanie Quayle's Jenga at the Fitzrovia Chapel in 2016 and Siân Davey's Looking for Alice in December 2017.

[11] As part of Frieze London, the Stephen Friedman Gallery has shown works by Yinka Shonibare CBE and Jonathan Baldock at the chapel.

[13] The Fitzrovia Chapel has been used by recording artists including Katie Melua, Allman Brown and the Vickers Bovey Guitar Duo.