The church has had several notable pastors including the Revd Samuel Martin (1842–78), G. Campbell Morgan (1904–17, 1933–43), John Henry Jowett (1918–22), Martyn Lloyd-Jones (1939–68), R. T. Kendall (1977–2002) and Greg Haslam (2002–16).

[2] Westminster Chapel has had five particularly well-known pastors: the Revd Samuel Martin (1842–78), G. Campbell Morgan (1904–17, 1933–43), John Henry Jowett (1918–22), Martyn Lloyd-Jones (1939–68), R. T. Kendall (1977–2002) and Greg Haslam (2002–16).

Prominent among the past deacons at Westminster Chapel have been Sir Fred Catherwood (1925–2014; son-in-law to Lloyd-Jones) and MJ "Monty" Micklewright (1897–1994).

[3] The reformed theologian John Murray also delivered a notable lecture here titled "The Heavenly, Priestly Activity of Christ" in 1958.

issued a "Mission, Vision, Values" brochure, stating that the church would be Spirit-led, prophetic, and be increasingly mission-minded.

About 70 students and people in their twenties currently attend the chapel, and the church has a dedicated team who minister to this age group.

[8] The full list of previous pastors is: The present chapel, completed in 1865, was designed by the architect William Ford Poulton (1822–1901) of Reading, Berkshire in a Lombard Romanesque Revival style.

The façade on Buckingham Gate is gabled and has a recessed triple-arched central porch, with graduated arcading above, all having decorative shafting.

There is a high platform or daïs toward the front of the chapel, accommodating the Communion Table and chairs for the presiding minister and the serving deacons.