Flat Creek is a stream in Barry and Stone counties of southern Missouri.

[3][4] From its headwaters near Washburn, the stream flows northeast parallel to Missouri Route 37 passing through southeast Cassville.

It continues to the northeast until meeting Little Flat Creek south of McDowell.

The stream course begins to meander turning east and passing under Missouri Route 39 north of Cato.

It meanders east passing into Stone County to enter the James River arm of Table Rock Lake after passing under Missouri Route 173 north of Cape Fair.