Dutch and Flemish Renaissance painting, of which Antwerp became the centre, covers the period up to about 1580 or later, by the end of which the north and south Netherlands had become politically separated.
The leading artist was Pieter Brueghel the Elder, who avoided direct Italian influence, unlike the Northern Mannerists.
After the Siege of Antwerp (1584–1585), the Southern Provinces of the Netherlands ("Flanders") remained under Spanish rule and were separated from the independent Dutch Republic.
Although many artists fled the religious wars and moved from the Southern Netherlands to the Dutch Republic (see Dutch Golden Age painting), Flemish Baroque painting flourished, especially in the Antwerp school, during the seventeenth century under Rubens, Anthony van Dyck, and Jacob Jordaens.
Following the deaths of major artists like Rubens in 1640 and the end of the Eighty Years War in 1648, the cultural significance of Flanders declined.