[4] The game involves two or more players who assume the control of a hero, a character with equipment, abilities and set of cards.

There are seven different card types, such as hero, equipment, weapon, action, reaction (attack and defense) and instant.

Each hero has intellect and life points, and is in one of ten classes: Assassin, Brute, Guardian, Illusionist, Mechanologist, Ninja, Ranger, Runeblade, Warrior, or Wizard.

[9] In October 2023, the company established Social Play game store events for casual players.

[9] In November 2022, the company organised the first Flesh and Blood World Championships in San Jose, California, with a prize pool of $300,000.

[12] Andrew Smith from the website Board Game Quest compared it to Magic: The Gathering, but noted that Flesh and Blood was easier to learn.