[1] A religious landscape painting, its "bold brushwork and exhilarating use of color" have led to it being described as one of Titian's masterpieces, as well as one of his earliest.

[3] Flight into Egypt depicts the biblical voyage of the newborn Jesus, along with Mary and Joseph as described in the Gospel of Matthew.

[4] The Gospel describes the Holy Family fleeing as the result of a vision from an angel, who told Joseph to bring them to Egypt since King Herod would be coming to kill the baby Jesus.

[8] Generally speaking, however, Flight into Egypt is primarily a religious history painting, depicting one of the earliest events in the life of Jesus described in the Gospels.

Although the members of Holy Family, the main subjects of the painting, are not directly centered in the canvas, their representation is framed around this central image of Mary and Jesus, with Mary, regarded as the greatest saint within Catholicism, caring for the infant Jesus on the family's journey to safety in Egypt.