That same year, Flora became a stop on the newly constructed Yazoo and Mississippi Valley Railroad.

The railroad depot is now a museum and is listed on the National Register of Historic Places.

[4] In 1941, the Mississippi Ordnance Plant was constructed north of Flora to produce propellant and igniter charges for large-caliber guns during World War II.

They were allowed to work in the higher paying production jobs only if white men were not available.

[6] But standards since then are more refined, and the site was dangerously contaminated due to the production and heavy armaments.

In 1947, the Mississippi Department of Education planned to adapt part of the plant into a vocational school for African Americans, until white residents protested to the governor, stating that property values would be ruined.

[9] One of the reinforced bunkers eventually became used for the "Southern Vital Records" storage facility.

In 1977, a local high school student found an abandoned M-2A2 tank in a wooded area.

[10][11] In 2008, the U.S. Department of Homeland Security announced that the Flora Industrial Park was one of six locations in the United States being considered for the construction of a new National Bio and Agro-Defense Facility.

Flora's mayor, Scott Greaves, had responded to opposition to the facility in 2007, saying, "Education is the whole key to it.

All of the streams eventually flow northwest to the Big Black River, a tributary of the Mississippi.

[citation needed] As of the 2020 United States Census, there were 1,647 people, 652 households, and 503 families residing in the town.