Florence is a city in Rankin County, Mississippi, United States.

According to the United States Census Bureau, the city has a total area of 5.9 square miles (15 km2).

[citation needed] The current city limits have grown northward towards Richland.

The city has grown both eastward and westward and will continue to expand towards the Pearl River, eventually stopping at the Pearl River, which separates Rankin County from Hinds County.

As of the 2020 United States Census, there were 4,572 people, 1,583 households, and 1,204 families residing in the city.