It is a part of the South Carolina Technical College System.

The Florence-Darlington Technical Education Center was established in 1963 and serves Florence, Darlington, and Marion counties.

Its original campus of less than 10 acres (4.05 ha) has expanded to nearly 240 acres (97 ha) with a modern complex of eight major buildings totaling nearly 350,000 square feet (33,000 m2).

The college operates sites in Hartsville, Lake City, and Mullins.

The college also operates a large health sciences complex in downtown Florence entirely devoted to careers in the health arena.