Florence Avenue runs through the cities of Inglewood, Los Angeles, Huntington Park (where it intersects Pacific Boulevard), Bell, Bell Gardens, Downey, Santa Fe Springs, and unincorporated Los Angeles County bordering the City of Whittier.

The Metro K Line serves three light rail stations on Florence Avenue, with the Fairview Heights station in Inglewood at West Boulevard near the border adjacent to the Hyde Park neighborhood of Los Angeles, the Downtown Inglewood station at La Brea Avenue in Downtown Inglewood and the Westchester/Veterans station at Hindry Avenue near the border adjacent to the Westchester neighborhood of Los Angeles.

[1][2][3][4][5][6][7] Land developer George E. Longan in 1927 established a new business center on Redondo Boulevard near Hillcrest Avenue, Inglewood, a Spanish stucco structure "in harmony with the nearby Inglewood Woman's Club.

[9] In 1934, the Los Angeles Times noted that "Florence Avenue runs into Redondo Boulevard.

[10] The intersection of Florence and Normandie is noted for an attack during the 1992 riots in Los Angeles when several black men pulled white driver Reginald Denny from his truck and beat him in the intersection.