[6] It hosted the infamous eighth WWE In Your House pay-per-view in 1996, during which a storm knocked out the power and thus the broadcast signal during the event.
In 2019, an indoor football team called the Carolina Havoc of the American Arena League, is announced to begin play at the Florence Center for the 2019 season.
[7] The building was the home of the South Carolina Fire Ants of Major League Roller Hockey in 1998, two ice hockey teams: the Pee Dee/Florence Pride (1997–2005) and the Pee Dee Cyclones (2005–2007), two indoor football teams: Carolina Stingrays (2004) and Florence Phantoms (2006–2009), two basketball teams: the Florence Flyers and the Pee Dee Vipers, and to the Florence Symphony Orchestra.
The venue currently hosts the South Carolina High School League championships in basketball (since 2024) and wrestling (beginning in 2025).
The Florence Center has hosted: Sent by Ravens (from Hartsville) in '11, Lady A in '11, Willie Nelson in '13, Marshall Tucker Band with Charlie Daniels Band in '13, The Beach Boys in '13, Switchfoot with Needtobreathe in '15, Mary J. Blige in '15, and Boyz II Men in '19.