The Coliseum is the current home of the South Carolina Stingrays, a minor league professional ice hockey team that plays in the ECHL.

The Coliseum has served as the venue for several televised events, to include In Your House 8: Beware of Dog pay-per-view after the Florence Civic Center's infrastructure failed (1996), WCW Uncensored (1997), Shania Twain (2004), WWE Raw (2002, 2005, 2006, 2007, 2013, 2015), PBR Built Ford Tough Series (2006), Wheel of Fortune (2006), and American Idol (2007, 2011) and The X Factor (2013) auditions.

Other major concerts and events have included KISS playing their final show with the original lineup (2000), where drummer Peter Criss smashed his Drumset as frustration over contract issues, Oprah Winfrey (2006), Walking with Dinosaurs (2008), a CNN Presidential Debate (2012), a Fox Business Presidential Debate (2016), Kid Rock (2008, 2011), Taylor Swift (2009), The Dave Matthews Band (in 1996, and since 2005), Kenny Chesney (2011), Jay-Z (2013), Brad Paisley (2011, 2014), Prince (2011).

The Coliseum hosted Metallica in '93 Nowhere Else to Roam Tour, Columbia's Hootie & the Blowfish with Greenville's Edwin McCain in '95, Gainesville's Tom Petty and the Heartbreakers in '95, Athens GA's R.E.M.

in '95, Green Day in '95, Macon GA's Allman Brothers Band in '96, Pearl Jam in '96, Stone Temple Pilots in '97, Jay-Z in '99, and N'SYNC in 2000.

The Coliseum hosted Ben Folds in '03, Breaking Benjamin with Staind and 3 Doors Down '05, Three Days Grace with Nickelback '07, The Fray '07, Kings of Leon '09, John Mayer '10, Daughtry with Lifehouse '10, Charleston's Darius Rucker in '11, Avril Lavigne '13, Fall Out Boy '16, Impractical Jokers '16, Meghan Trainor '16, Twenty One Pilots '17, The Chainsmokers '17, Ed Sheeran '17, Mumford & Sons '19, Trevor Noah '19, and Five Finger Death Punch in '19.

[10] In September 1992, the City Council approved $879,000 to fund installation of an ice rink in the coliseum, which at that time was scheduled for completion by December 26 of that year.

[11] The ECHL Board of Governors met in November 1992 to vote on bringing a hockey franchise (whose application had been pre-approved that April) to the Charleston area.

[12] At that meeting, the league approved creation of the expansion franchise for the 1993–94 ECHL season, giving the coliseum its first professional sports team as a tenant.

The expansion consists of extensions built onto the Coliseum's north and south entrances, increasing concourse space by 20,000 square feet (1,900 m2) and adding up to 40 additional points of sale for concessions.