[5] On December 26, 1921, Black American male Bill McAllister was lynched for having an affair with a white woman.

[7] As of the 2020 census, there were 137,059 people, 53,047 households, and 35,763 families residing in the county.

Along with Darlington County, it comprises part of the Florence, SC Metropolitan Statistical Area.

In 2020, Florence County Sheriff Kenney Boone pled guilty to embezzlement and misconduct in office.

[22] As part of the “Solid South,” Florence County was strongly Democratic throughout its early existence.

In recent years, though, Florence has shifted to a Republican-leaning county, having not voted Democratic at the presidential level since Jimmy Carter in 1976.

In 2020, incumbent Republican president Donald Trump narrowly carried Florence County, winning 32,615 votes (50.56%) to 31,153 (48.29%) for Democratic candidate Joe Biden.

Typically, Democratic strength is concentrated in the City of Florence, while the suburban and rural areas lean strongly Republican.

Most of the county is located within the state's 7th congressional district, which is represented by Republican Russell Fry.

A small portion of the county, specifically the areas around Lake City, is located in the majority-minority 6th district, and is represented by Democrat Jim Clyburn.

[26] Duke Energy, Francis Marion University, GE HealthCare, Honda, McLeod Health, Otis Worldwide, QVC, Ruiz Foods, and Walmart are some of the largest employers in the county.