Born in Tacoma, Washington, Deshon began her film career in 1915, appearing in The Beloved Vagabond, and would later star in numerous pictures for Samuel Goldwyn and Vitagraph Studios between 1918 and 1921.

In 1919, while living in New York, she was summoned by Samuel Goldwyn to Los Angeles, California, and offered her work in his studio.

Her final film credit was in the role of Sally McTurk in The Roof Tree, directed by John Francis Dillon.

[7] On February 4, 1922, Deshon was found unconscious on the third floor of her apartment building at 120 West Eleventh Street.

However, rumors persisted among her circle of friends and acquaintances that she might have committed suicide, and several biographers, including Ross Wetzsteon[7] and Christoph Irmscher,[2] have described her death as such.