[citation needed] While she was still studying in college, Kasumba landed her first professional film role, Silke, in the Dutch motion picture hit Ik ook van jou.

Florence Kasumba travelled to New York City and was cast in the title role in Germany's premiere production of Elton John's international hit musical Aida.

Kasumba reprised the character, Ayo, a member of the all-female Dora Milaje fighting squad,[2] in the Black Panther solo film,[3] Avengers: Infinity War, and the streaming series The Falcon and the Winter Soldier.

In 2019, Kasumba landed the character of Shenzi in the animated remake, The Lion King (2019) directed by Jon Favreau, alongside Keegan-Michael Key and Eric André as Kamari and Azizi.

She was nominated for the Black Entertainment Film Fashion Television & Arts Award for International Rising Star in 2016, against Lupita Nyong'o, John Boyega and Lisa Awuku.