Initially, the focus was on three main characters and their friendship Dr. Roland Heilmann, Dr. Achim Kreutzer, and Dr. Maia Dietz.
Other locally renowned directors from the former GDR that have contributed to the program include Celino Bleiweiß, Klaus Gendries, and Peter Hill.
As of 2016, the cast consists of the following actors: In July 2014, the MDR announced the production of a spin-off named In aller Freundschaft – Die jungen Ärzte [de] - (In All Friendship - The Young Doctors).
The production of 42 episodes took place since autumn 2014, the weekly broadcast on Thursday evenings began on 22 January 2015 at Das Erste.
In Die jungen Ärzte, two of the main characters, Luisa and Jasmine, who have applied to the nursing school, have a car accident in Erfurt (where the young doctors show happens) and meet Fliete Petersen, the cousin of Elias Bähr, who works at the Johannes-Thal-Klinikum as a assistants.