It follows Woodward Avenue just south of the Florida State University campus, between Gaines Street (SR 371) and Jefferson Street.

[2] SR 157 is a short two-lane road and maintains a 25 miles per hour (40 km/h) speed limit.

North of its terminus at Jefferson Street, Woodward Avenue continues north for two more blocks before becoming a pedestrian pathway through the FSU campus.

North of campus, Woodward Avenue resumes its course without a state designation.

The entire route is in Tallahassee, Leon County.