State Road 291 (SR 291) is a major thoroughfare in the Pensacola, Florida metropolitan area.

It runs from Wright Street in downtown Pensacola north to its terminus at Nine Mile Road (U.S. Highway 90 Alternate or US 90 Alt.)

Between Fairfield Drive (State Road 295) and University Parkway, Davis is one of the city's major commercial strips.

For a time at least during the early 1950s, US 90 was routed along SR 291 north of Cervantes Street.

[citation needed] The entire route is in Escambia County.