The highway crosses the Caloosahatchee River via the Wilson Pigott Bridge, a small drawbridge, a mile north of the southern terminus.

The southern terminus is with an intersection of SR 80 near Fort Myers Shores.

The route is home to G. Pierce Wood Memorial Hospital, replacing the old De Soto Aircraft Field.

In 2006, Cameratta Properties purchased 5,860 acres (24 km2) of land along SR 31 in Charlotte County for a master-planned community that upon completion will add approximately 17,000 homes and 500,000 square feet (50,000 m2) of retail and office space.

[5] This segment, locally known as Airport-Pulling Road, became (CR 31) when it was turned over to county control in the 1980s.