As the road runs along the north side of some agricultural land, it eventually meets with a railroad crossing and then passes a sawmill before encountering US 41 (SR 45) at a section of Pasco County which is known as Gowers Corner.

Other sites along this segment include the Dirt Devil's Speedway[3] and a concrete factory on the southwest corner of CR 583 (Ehren Cutoff).

A winery was established at some point in the early 21st Century, and a model aviation club existed in one of two locations along this road segment.

Almost immediately, the road enters the unincorporated hamlet of Pasco[4] as it crosses a former railroad right-of-way that once ran from St. Petersburg to Trilby.

[5] The interchange with I-75 (exit 285) is easily visible before reaching the former grade crossing, but not without approaching a gated community and two truck stops.

Continuing east, SR 52 bisects the Mirada development before intersecting CR 577 (Curley Road) immediately south of San Antonio.

Continuing east south of St. Leo, SR 52 curves northeast to avoid Williams Cemetery before intersecting with CR 579 (Prospect Road) on the southeast side of the town.