Between the Indian River and Newfound Harbor, it crosses through Merritt Island, intersecting SR 3.

From 2002 to 2007, the Florida Department of Transportation (FDOT) widened the 22-mile (35 km) stretch to four lanes.

A 1935 law extended SR 206 west to Orlando along the planned Cocoa–Orlando Highway, which used Lake Road in the Cocoa area.

A branch would run north along the west side of the Banana River to connect with pre-1945 SR 219 at Orsino.

It used very little of the existing Taylor Creek Road, instead being built further west, joining SR 50 much closer to Bithlo than Christmas.

At some point, Alafaya Trail was taken over from SR 50 north past the University of Central Florida to downtown Oviedo.