It is the most direct route to Siesta Key when traveling west on SR 70 from Arcadia and Fort Pierce.

A block west of the eastern terminus is CR 661, an alternative of U.S. Route 17 and provides access to State Road 60 (via SR 37).

SR 72 curves east again and runs through rural areas of woods and swamps.

The road enters Myakka River State Park and turns southeast.

SR 72 leaves Myakka River State Park and passes through areas of fields and trees.

The road crosses into DeSoto County and continues through rural areas for several more miles, intersecting CR 769.

[5] The four-lane bascule bridge carrying Stickney Point Road to Siesta Key was built in 1968.

[11] County Road 72A (CR 72A) is a west-to-east suffixed alternate of SR 72.

After the intersection of Cattleman Road and Grove Point Boulevard, the road narrows down to a two-lane undivided highway before crossing over I-75 with no access, then returns to ground level after a power sub-station on the northeast corner of the overpass.