West of US 301, Fruitville Road continues as an unnumbered four-lane divided highway under city control to an intersection with US 41/SR 45 in Downtown Sarasota.

Past this interchange, SR 780 comes to its eastern terminus, with Fruitville Road continuing east as CR 780.

[5] US 41 (Tamiami Trail) was concurrent with SR 780 along Main Street through Downtown Sarasota between South Palm Avenue and Washington Boulevard until 1959, then US 41 was rerouted to the newly-built Bayfront Drive.

[6] In the late 1980s, the west end of Fruitville Road was realigned and extended to US 301 (Washington Boulevard) at 3rd Street in Sarasota.

[8] Main Street also came under city control after the realignment, and the John Ringling Causeway was redesignated as part of SR 789.