His uncles Jeff and the late Roger Mayweather were professional boxers, with the latter—Floyd's former trainer—winning two world championships, as well as fighting Hall of Famers Julio César Chávez, Pernell Whitaker, and Kostya Tszyu.

[32] He was nicknamed "Pretty Boy" by his amateur teammates because he had relatively few scars, a result of the defensive techniques that his father and uncle (Roger Mayweather) had taught him.

[37] Referee Hamad Hafaz Shouman of Egypt mistakenly raised Mayweather's hand (thinking he had won), while the decision was announced giving the bout to the Bulgarian.

[39][40] "I refuse to be part of an organization that continues to conduct its officiating in this manner", Waeckerle wrote in his letter of resignation to federation president Anwar Chowdhry.

[54] Before making the fifth successful defense of his title against former WBC Featherweight Champion Gregorio Vargas in early 2000, Mayweather fired his father as his manager and replaced him with James Prince.

Larry Merchant stated, "Mayweather fights in a tradition of boxing and quick handedness that goes back in Michigan, all the way to fighters like Sugar Ray Robinson".

"I guess he thinks he's going to stand there and let him hit him on the arms all night," said Futch, who correctly predicted that Mayweather would completely dismantle Corrales in a defensive masterpiece.

[76]On May 26, 2001, Mayweather, fighting in his hometown of Grand Rapids, pounded out a 12-round unanimous decision over future IBF super featherweight titleholder Carlos Hernández to retain his WBC super-featherweight title.

He defeated Castillo, winning the WBC and vacant The Ring and lineal lightweight titles with a 12-round unanimous decision at the MGM Grand Garden Arena before a crowd of 6,920.

During the run-up to the fight Nelson Mandela invited N'dou to his office for a pep talk before his departure for the U.S., advising him to "keep Mayweather on the outside with the jab, work the body and the head will become available".

[106] Five days after the fight, the Nevada State Athletic Commission (NSAC) decided not to overturn the result of the bout; however, Roger Mayweather was fined $200,000 and suspended for one year.

[citation needed] He also captured his third lineal championship in as many weight classes (super featherweight, lightweight and welterweight), following in the footsteps of Henry Armstrong and Sugar Ray Leonard.

During the tenth round, Hatton was caught by a checked left hook thrown from Mayweather's hip; after falling headfirst into the turnbuckle, he hit the floor.

[118] On May 2, 2009, it was confirmed that Mayweather was coming out of a 21-month retirement to fight The Ring lightweight champion and #2 pound-for-pound Juan Manuel Márquez, at a catch weight of 144 lb on July 18 at the MGM Grand in Las Vegas on HBO PPV.

[120] However, it was later revealed that the contract was changed so that Mayweather could make weight within the welterweight limit of 140–147 lb as long as Marquez received a large guarantee.

[129] On December 5, 2009, ESPN reported that eight-division world champion Manny Pacquiao had allegedly signed a contract to fight Floyd Mayweather on March 13, 2010.

"[130] On December 11, 2009, an eight-page contract was sent by Golden Boy Promotions on behalf of Mayweather to Top Rank, representing Pacquiao, proposing a 50–50 financial split between the sides for a fight on March 13, 2010.

[133] On December 13, 2009, Pacquiao's adviser, Michael Koncz, dismissed Mayweather's request for Olympic-style drug testing as inconsequential, stating, "Our reaction is, 'So what?'

After negotiations with Manny Pacquiao failed again, on February 1, 2012, it was confirmed that Mayweather would be moving up in weight to fight WBA super welterweight champion and The Ring #1-ranked light middleweight Miguel Cotto.

[144] Mayweather earned the biggest guaranteed purse in boxing history ($32 million) when he fought Cotto, according to contracts filed with the Nevada State Athletic Commission.

[146] On June 1, 2012, Mayweather reported to the Clark County Detention Center in Las Vegas to serve his jail term for domestic abuse.

Compubox stats showed Mayweather's dominance in the fight, landed 232 of 505 punches (46%) and 117 connected of 526 thrown (22%) for Álvarez, who earned a base purse of $5 million.

"[179][180] On July 6, 2015, the World Boxing Organization (WBO) stripped Mayweather of his welterweight championship because he was not permitted to hold titles in multiple weight classes, and because he failed to pay a sanctioning fee.

[182] Berto believed Mayweather chose him as his final opponent for personal reasons, which could date back to when he won the National Golden Gloves tournament.

[205] In front of a crowd of 14,623, Mayweather won via TKO in the 10th round, surpassing Rocky Marciano and setting the record for the longest active unbeaten streak in a professional career at 50–0.

[239] From the fourth round onward, Paul was visibly fatigued and took every opportunity to utilize his weight advantage by tying the smaller Mayweather up in the clinch after every exchange.

[250] The bout – held at the FLA Live Arena in Sunrise, Florida – was stopped by referee Kenny Bayless in the sixth round, prompting a ring invasion by members of each boxer's teams.

[256] He interfered with a tag-team match, which resulted in a loss for the Big Show (again a heel) and his partner Chris Jericho as Mayweather gave MVP brass knuckles to knock Jericho out, giving MVP and his new tag-team partner Mark Henry the win and a shot at the Unified WWE Tag Team Titles at WWE Breaking Point against Jeri-Show.

[266] In 2004, Mayweather was given a one-year suspended jail sentence, ordered to undergo counseling for "impulse control" and pay a $1,000 fine (or perform 100 hours of community service) after being convicted of two counts of misdemeanor battery against two women.

[277][278] In December 2022, Central California U.S. District Court Judge Michael W. Fitzgerald dismissed the lawsuit on the basis that the claims were insufficiently supported given heightened pleading standards for fraud.