Floyd Davidson Spence (April 9, 1928 – August 16, 2001) was an American attorney and a politician from the U.S. state of South Carolina.

He lost a contested seat that year for United States Representative from South Carolina's 2nd congressional district to Democrat Albert W. Watson, who had the support of powerful senator Strom Thurmond.

Born in Columbia, the capital of South Carolina, Spence spent most of his life in nearby Lexington County.

Shortly after graduating from high school, he enlisted in the United States Navy Reserve, from which he retired in 1988 as a captain.

He was reelected in 1958 and 1960, but on April 14, 1962, Spence announced that he was switching to the Republican Party, having become uncomfortable with the national Democrats' increasingly liberal platform.

Watson defeated Spence with 53 percent of the general election vote, the closest congressional race in South Carolina in memory.

The 2nd had a conservative bent; the area's old-line Democrats had begun splitting their tickets in national elections as early as the 1940s.

Both he and Watson represented conservative whites, rather than the majority African-American Republicans in South Carolina who had supported the party of Abraham Lincoln.

In 1974, Spence defeated challenger Matthew J. Perry, an African-American Democrat who had made his reputation in civil rights cases.

By this time, the district had become very racially polarized, with African-American voters making up much of the Democratic base while whites supported Republicans.

He had been admitted to St. Dominic Hospital in Jackson, Mississippi, three weeks earlier for testing and treatment for nerve pain in his face.

[10] Upon Spence's death, his former aide, Republican State Senator Joe Wilson, won the special election for the vacant seat.