[3] Patented in 1958 and approved for medical use in 1978,[4] it is on the World Health Organization's List of Essential Medicines.

[5] Temporary nose and throat dryness, irritation, bleeding, or unpleasant taste or smell may occur.

[2] Rare but localized infections of the nose and pharynx with Candida albicans have also been reported.

[3] Corticosteroid nasal sprays may affect the hypothalamic-pituitary-adrenal axis function in humans.

[7] After obtaining the desired clinical effect, the maintenance dose should be reduced to the smallest amount required to control the symptoms.