As perfluorinated compounds (PFCs), all Fluorinert variants have an extremely high global warming potential (GWP),[1] so should be used with caution (see below).
[3] Usage of fluorinated oils should be limited to closed systems and reduced volumes, since they have a very high global-warming potential and a long atmospheric lifetime.
[4] Although Fluorinert was intended to be inert, the Lawrence Livermore National Laboratory discovered that the liquid cooling system of their Cray-2 supercomputers decomposed during extended service, producing some highly toxic perfluoroisobutene.
The science-fiction film The Abyss (1989) depicted an experimental liquid-breathing system, in which the use of highly oxygenated Fluorinert enabled a diver to descend to great depths.
While several rats were shown actually breathing Fluorinert, scenes depicting actor Ed Harris using the fluid-breathing apparatus were simulated.