The brewery incorporated in 1995, opened for business in 2000, was started by two majority partners, Phil Internicola and Tim Herzog, along with 25 individual investors.

It presently distributes its products to bars, restaurants and retail outlets in Erie, Niagara, and Chautauqua counties.

Flying Bison attributed a rise in the cost of ingredients to severe financial difficulty which caused a brief halt in production in 2010.

In 2014, the company announced their intention to build a new brewery in the Larkinville district of Buffalo, vacating their longtime home on Ontario Street.

It will increase their output to as much as 10,000 BBL annually, grow jobs from ten to 16 employees, and add a taproom and patio space for events and sales by the pint.