[1] Focal hyperhidrosis is sometimes referred to as The Silent Handicap,[2] as it has a significant impact on the quality of life, affecting the individual socially, psychologically, emotionally and professionally.

[3] In 2006, researchers uncovered that primary palmar hyperhidrosis, referring to excess sweating on the palms of the hands and feet, maps to the gene locus 14q11.2-q13.

[8] Typical regions of excessive sweating include the hand palms, underarms, the sole of the foot, and sometimes groin, face, and scalp.

[10] The Canadian Hyperhidrosis Advisory Committee has published a comprehensive set of guidelines which outlines key aspects of treatment related to this condition.

[3] In addition to topical antiperspirants (whose main active ingredients usually are aluminum or zirconium salts) treatment options include: iontophoresis (hands, feet), onabotulinum­toxinA (Botox) injections (underarms, hands, feet, and other localized areas),[11] electromagnetic/microwave energy thermolysis of underarm sweat glands (miraDry),[12] laser-assisted removal of the sweat glands (underarms),[13] other local procedures such as liposuction and curettage of the sweat glands (underarms), medications of the anticholinergic type that are taken by mouth, and sympathectomy surgery for sweating of the hands or head that can't be controlled by other means.