With a redesigned body and chassis, and marketed as its F-150 line, between the company's Ranger and the Super Duty trucks.

The eleventh-generation F-Series was assembled by Ford at numerous facilities in the United States, Canada, and Mexico; with either a 4.6-liter V8, a 5.4-liter three-valve-per-cylinder V8, or a 4.2-liter V6, the latter only available in regular-cab 4×2 trucks.

Other updates included improved front seats with revised side bolstering, and new 20" wheels available for FX4, Lariat, and King Ranch.

Other mid-cycle revisions included five-inch running boards, traction assist on 4×2 V8 models, and "Smokestone Clearcoat Metallic" paint for the Lariat trim.

Beginning with the second half of the 2007 model year, Ford offered the Saleen forced-induction package on the Harley-Davidson edition as an OEM option.

[5] The Heavy Duty Payload Package (HDPP) marked a significant advancement from the prior-generation F-150, which had a 7,700-pound GVWR.

The HDPP introduced several enhancements, including a reinforced frame and suspension, LT245/70R17D BSW all-season tires mounted on 17-inch steel seven-lug rims, and a more robust 10.25-inch rear axle with a 4.10:1 ratio (optionally with limited-slip differential), resulting in an increased GVWR of 8,200 pounds.

It also beat the three-time winning Chevrolet Silverado for Car and Driver magazine's Best Pickup Truck for 2004 and 2005.

[9] It was also named the Winner of the 2006–2007 Golden Icon Award (presented by Travolta Family Entertainment) for "Best Truck.