Alongside the naming change, this generation marked several firsts for the F-Series, including an adjustable seat (wide enough for three people),[6] power brakes,[7][8] and the introduction of the Ford-O-Matic automatic transmission as an option.

Along with increasing payload capacity, designers redesigned the suspension to improve steering control.

[10] Shortened to a 110-inch wheelbase (from 114 inches), the front axle was moved rearward to further improve turning radius and lower the hoodline.

[11] A 20-inch-deep cargo bed was introduced; though the width would change, the depth remained the same through the seventh-generation F-Series of 1980.

[9] Distinguished by a two-bar grille, the 1953 F-Series internally denoted the 50th anniversary of Ford Motor Company with a commemorative emblem on the steering wheel horn button.

[10] The powertrain lineup saw further change; along with a newly enlarged 223 cubic-inch inline-6 base engine (increased to 115 hp),[12] the Flathead V8 (which made its debut in the 1939 Mercury) was discontinued.

Again using a 239 cubic-inch displacement, the overhead-valve 130 hp Y-Block V8 brought a significant increase in power output.

The six-cylinder engine's displacement was also increased, from 215 to 223 CID, and power steering was introduced as an option.

[3] Alongside the medium-duty and Big Job F-Series conventional-cab trucks, Ford sold the C-Series COE, configured with a raised cab and shortened hood.