The program premiered on April 1, 2005, and for three seasons was hosted by author and journalist Fareed Zakaria.
Beginning in January 2008, journalist Daljit Dhaliwal became the new host and the title of the program was changed accordingly.
The program explores current international issues in conversations with journalists, politicians, and other newsmakers, and examines America's role in an increasingly globalized world.
Through a partnership with the citizen journalism website Helium.com, the program offered viewers an opportunity to get their voices heard on the most pressing global issues.
The issues were chosen by Foreign Exchange and ranged from Kosovo as an inspiration to other independence movements in the world to the future of socialism in Latin America.