[3] During the First Seminole War, Fort Crawford served as a base of operations for raids against Red Sticks in the Florida Panhandle.

General Gaines wrote to Jose Masot, the governor of West Florida, to ask permission for supplies to be sent up the Conecuh River from Pensacola.

Masot did agree to release hostile Creeks into the custody of the United States for transportation back to Fort Crawford.

[10] In a letter to George W. Campbell, Jackson listed the seizure of Fort Crawford's supplies (along with Spain's harboring of hostile Creeks) as his reason for invading Pensacola on May 23, 1818.

[11] After the Adams–Onís Treaty took effect in 1821, Florida was ceded to the United States and Fort Crawford was no longer needed for its original use.